If there’s one takeaway from dining out during the pandemic, it’s that outdoor air is safer than indoor air. In that vein, a recent SciTechDaily article discussed a new type of UV light that makes the former as safe as the latter. A study conducted at Columbia University Vagelos College of Physicians and Surgeons found that ceiling-mounted far-UVC lights significantly reduced indoor person-to-person transmission of airborne diseases such as COVID-19 and influenza. In fact, it can reduce the amount of indoor airborne microbes by 98% in just five minutes.

Scientists have known for decades that conventional germicidal UVC light can rapidly kill bacteria and viruses, but it can’t be used indoors as it’s a potential health hazard that can damage the skin and eyes. far-UVC light, however, is just as effective but since it has shorter wavelengths, it can’t penetrate living human skin cells or eye cells. But it can kill microbes, which are significantly smaller than human cells. That’s as much proof as I need. Now let’s make all lights far-UVC and move on with our lives.

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Administering a coronavirus test at a drive-through testing site in Hagerstown, Md., last month.Credit…Kenny Holston for The New York Times

The highly contagious Omicron subvariant known as BA.2, which led to a surge of coronavirus cases in Europe, is now the dominant version of the virus in new U.S. cases, according to estimates from the Centers for Disease Control and Prevention on Tuesday.

Last week, the World Health Organization reiterated that BA.2 was the dominant version of Omicron around the world, and Dr. Rochelle Walensky, the director of the C.D.C., said she anticipated it would soon become dominant in the United States.

Scientists have been keeping an eye on BA.2, one of three genetically distinct varieties of the Omicron variant of the coronavirus, which was discovered by South African researchers in November.

BA.2 was first identified in the United States in December, and it accounted for about 55 percent of new U.S. cases in the week ending Saturday, according to C.D.C. estimates on Tuesday. The figures are rough estimates subject to revision as more data comes in, as happened in late December, when the agency had to significantly decrease its estimate for the nationwide prevalence of the BA.1 Omicron variant. Before that, the Delta variant had been dominant since July.

Cases of Omicron can only be confirmed by genetic sequencing, which is performed on just a portion of samples across the country. The C.D.C.’s estimates vary in different parts of the country. BA.2 was found in a high proportion of samples in the Northeast, and a lower proportion of samples in the Midwest and Great Plains.

BA.1, which became dominant in late December, was almost entirely responsible for the record-shattering spike in U.S. cases this winter, but earlier this year, BA.2 started to account for a larger proportion of new infections. Its rapid growth is attributed in part to eight mutations in the gene for the spike protein on the virus’s surface, which are not found in BA.1.

While BA.2 is more transmissible than BA.1, it has not been shown to cause more severe illness and vaccines continue to protect against the worst outcomes. Many U.S. health officials have said they expect case numbers to rise without a major surge caused by BA.2, but other scientists worry that the nation isn’t doing enough to prevent another possible surge.

In the U.S., the seven-day average of new cases has dropped significantly from the height of the Omicron BA.1 surge. Though the decrease has slowed in recent days, the average has hovered this past week about 30,000 cases per day, a level last seen in July, according to a New York Times database.

Covid hospitalizations plummeted in the last two weeks by about 35 percent, to about 18,000 per day. Intensive care unit hospitalizations have fallen, too — by about 42 percent, to under 3,000.

And about 750 coronavirus deaths are being reported each day in the U.S., the lowest daily average since before the Omicron variant took hold late last fall. The last time the rate was this low was in mid-August.

In some European countries, the rise of BA.2 came at the same time as a surge in new cases. In the Asia-Pacific region, Hong Kong, South Korea and New Zealand, all of which suffered relatively little from earlier variants, are now getting walloped by BA.2.

Vaccines continue to protect people against severe disease, especially those who received a booster, experts have repeatedly said.

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Introduction

Asthma is one of the most common chronic conditions of childhood, impacting up to 10% of children in North America and over 7 million children in the United States.1–4 There is a substantial economic burden associated with asthma, with an estimated cost of $81.9 billion dollars in 2013 in the United States.5 In particular, poorly controlled asthma carries significant direct and indirect economic costs including healthcare utilization and school/work days lost.6

Figure 1 There are three aspects to the cellular and chemical pathology of asthma: the epithelial and subepithelial response the subsequent inflammatory process; and the impact on airway mucus and bronchoconstriction. When children with asthma inhale an aeroirritant, there is a complex interplay of cells and chemical that is poorly understood. The main chemical players are called “alarmins”, and these link with cells such as Antigen-Presenting Cells and Dendritic Cells. These drive a shift in the types of T-cells that a person has. In most people with asthma there is an imbalance such that the undifferentiated T-helper cell (Th-0) is more likely to become a Th2, rather than Th1, cell. When this happens, people are said to have “Type 2-high” asthma; this is the usual phenotype in children. There are two main asthma endotypes in children with Type 2-high asthma – the eosinophilic pathway, and the IgE-mediated pathway. The key chemicals that drive these pathways include Interleukin 4/13 and Interleukin-5. Children exhibit these pathways and endotypes to varying degrees. There are other aspects of the pathogenesis, such as Th-17, which promote non-Type 2 inflammation. The consistent driver in children with Type 2-high asthma is that avoidance of aeroirritants in the first place significantly reduces the inflammatory load.

Recognition of asthma heterogeneity across age ranges has led to the identification of Clinical and/or data-driven clusters of patients with similar observable traits (phenotypes) and increasing research on possible underlying pathophysiological and molecular mechanisms (endotypes).7,8 Whilst many challenges remain in disentangling the causal pathways, stability and implications of asthma heterogeneity, childhood asthma is mostly driven by type 2-high allergen-associated airway inflammation, albeit this may not be the case across levels of severity and treatment (Figure 1).9,10

Environmental allergies are the best predictor of persistence of asthma throughout childhood.2 In addition, exposure to aeroallergens in those who are sensitized is a significant cause of asthma exacerbations in children with asthma.11 The National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group (NAEPP) recommends allergy testing for aeroallergens (in particular indoor aeroallergens) in those with asthma who require daily anti-inflammatory therapy.12 However, the role of allergen avoidance as a general strategy in children with asthma remains controversial.2 The role of immunotherapy (both subcutaneous and sublingual) in asthma management is also an evolving conversation.2

There is an increasing recognition that the exposure to aeroallergens is and will continue to be impacted by key drivers of an era of global change such as climate change, evolving lifestyles and the current COVID-19 pandemic. Importantly, its consequences are most felt by those facing adverse social determinants of health.13,14 In addition, allergen exposure needs to be placed in the context of the multifactorial nature of asthma exacerbations and outcomes, in particularly given the major role of viral infections, as wells as other contributing factors such as microbiome and genetics.

The goal of this introductory review are to (i) explore the state of the art on the relevance of exposure to various indoor and outdoor aeroallergens in asthma exacerbations and severity; (ii) to briefly describe the evidence-base for avoidance and treatment for sensitization to these allergens, and (iii) to address the impact of climate change, adverse social determinants, and the current COVID-19 pandemic on allergen exposure.

Allergens and Asthma Outcomes

Indoor Allergens

Children exposed to various indoor allergens are placed at an increased risk of developing asthma in later life, with sensitization in these individuals being a strong predictor of disease morbidity.15–18 Common indoor exposures for infants include house dust mite, pet, cockroach, mold and rodent allergens.18 Sensitization to at least one indoor allergen, has been demonstrated to be present in 9 out of every 10 children Hospitalised with asthma.19,20

Recently, there has been a behavioural shift in modern society/families towards spending more time indoors, thereby increasing the amount of allergen exposure for children.21,22 To add to this, the current climate of the ongoing COVID19 pandemic has seen a huge increase in time spent at home due to lockdowns/quarantine. There is also growing evidence to suggest children are exposed in other environments where they spend large proportions of their day (such as school or daycare/nursery) as well as in their homes.23–27

In Table 1 we present risks of the development of childhood asthma in relation to exposure to aeroallergens discussed in this paper (based on a published systematic reviews – please note these relate to exposure, rather than sensitisation, to allergens).28

Table 1 A Summary of Risks for Development of Childhood Asthma in Relation to Exposure to Allergens Described in This Review. (Based on Dick et al)28

House Dust Mite

House dust mite (HDM) is one of the most prevalent indoor aeroallergens and commonly studied in the context of childhood asthma.29,30 It is believed that up to 85% of asthmatic children in temperate climates are sensitized to either one or both Dermatophagoides pteronyssinus or Dermatophagoides farinae species.31,32 Two main groups of allergens (1 and 2) usually found in dust mite faeces are predominantly responsible for allergen sensitization.

Dust mite allergens can be found in reservoirs present in various places throughout the home, such as soft furnishings and toys, beddings, carpets etc.27 One cross-Sectional study conducted across 831 United States (US) homes found that 84.2% had detectable levels of house dust mite allergens.32 It was further found that approximately half of the homes had levels equal to, or greater than, the supposed threshold for allergic sensitization (>2ug/g).33

Most of the literature available highlights the detrimental impact dust mite sensitization can have on paediatric asthma outcomes.29–31 Chronic exposure to HDM is associated with increased bronchial-hyperresponsiveness and airway inflammation; often resulting in poor lung function. One birth cohort study comprising of 620 babies noted associations between HDM sensitization and the prevalence of wheeze during infancy.34 The study concluded that children with a positive skin prick test for HDM at ages 1 or 2 years was a predictive factor for wheeze at age 12 years (adjusted odds ratio [aOR]: 1 year, 3.31 [95% CI 1.59–6.91]; 2 years, 6.37 [95% CI, 3.48–11.66]). The study further reported that one-year olds with wheeze who were HDM-sensitized had a 75% (95% CI 51% to 91%) greater probability of a wheeze present at 12 years of age.34 This was considerably lower compared to a 36% (95% CI 23% to 50%) probability amongst those infants who were not HDM sensitized. Similarly, this is echoed by another study which found a significant association between HDM sensitization in children (aged 2 to 5) with wheeze and the persistence of asthma in later childhood (P = 0.03).35 Symptom severity was also assessed by a study in Australia involving 174 children.36 They found a significant increase in daytime cough (relative rate [RR]; 1.64: 95% CI 1.14–2.36), nocturnal wheeze (RR; 3.62: 95% CI 1.49–8.77) and daytime asthma attacks (RR; 1.95: 95% CI 1.06–3.60).36

Indoor Molds

Fungal aeroallergens, commonly known as “molds”, are found extensively in both indoor and outdoor environments,21 often in association with damp and water damage.21 Out of the small number of species that have been identified, Penicillium and Aspergillus are the most prevalent types found indoors.29 However, some “outdoor” species, such as Alternaria can also be found indoors due to transfer via open windows or directly through clothing and pets.21,37

Sensitization rates for fungal allergens can be high amongst children with more asthma morbidity, with one inner-city US study reporting a prevalence of 50%.38 Another study involving UK children with severe symptoms presenting to hospital, demonstrate that up to 76% of participants were sensitised to such allergens.39 This emphasises the link between exposure in mold-sensitive children and severity of their asthma symptoms.

Several systematic reviews and meta-analyses have confirmed the associations between exposure to mold and damp with increased asthma morbidity in children.40,41 One study, investigating Penicillium exposure in asthmatic children found that high levels were associated with increased frequency of symptoms (an excess of 1.19 maximum symptom days at P=0.03) and healthcare visits (OR; 1.13: 95% CI 1.04–1.24).38 Similarly, Alternaria exposure has also been shown to worsen symptoms and bronchial hyper-responsiveness in sensitised asthmatic children.42 Results showed that children sensitised to the Alternaria mold species were more likely to suffer from airway hyperresponsiveness than other children (OR; 1.99: 95% CI: 1.45–2.70).42 Qualitative research has also demonstrated that merely the presence of visible mold, or its odour within the home is associated with overall poor infant asthma control.43

There is conflicting evidence regarding the associations between early life exposure to mold and asthma severity in later childhood. Some studies suggest that exposure to a diverse range of fungal allergens after birth can in fact be protective against allergen sensitisation and subsequently asthma symptoms.41 Yet most evidence supports the detrimental impact mold exposure can have on the development of asthma in children.21 For example, a Boston birth cohort study reported that high Alternaria exposure within the first 3 months of life is associated with increased frequency of wheezing in later childhood (OR; 1.83: 95% CI 1.07–3.14).

With regards to sensitisation, it can be difficult to fully assess the true extent of fungal allergens since many species remain unidentified.21 Furthermore, it is also noted that there is great variability in the methods used to quantify and assess fungal allergens.

Pets

Unsurprisingly, cats and dogs are the most common type of pets in US homes, and therefore are usually the primary focus in the context of asthma development in children.44 Fel d 1 and Can f 1, respectively, are major cat and dog allergens and specific markers for sensitisation.21 These allergens are found on the skin, hair and in the saliva of these furry pets and can be transferred to household members via clothing and surfaces.21 Such allergens can also remain airborne for a period of time, thereby causing airway irritation when inhaled by susceptible individuals (eg, atopic children). Although found in homes without pets, allergen concentrations are believed to be up to 1000 times greater in those households with pets.18 Sensitisation to Fel d 1 and Can f 1 is prevalent amongst asthmatic children and subsequently associated with poorer asthma-related outcomes. Sensitization rates reportedly range from between 25% to 65% amongst children with asthma.45

A prospective birth cohort conducted by the National Asthma Campaign Manchester Asthma and Allergy Study followed children from birth to 3 years of age.46 They measured skin-prick tests, airway resistance and allergen levels against pet ownership in the home. They concluded that the combination of allergic sensitization and high levels of pet allergen exposure were linked to significantly reduced lung function in children with asthma.46 The results from a US population-based survey emphasise the combined effect of allergic sensitisation and prolonged allergen exposure on asthma outcomes in children.44 For children sensitized to either cat or dog, there is a significant association with current asthma (reported sensitivity effect [SE] 17.3; 95% CI 9.3–25.4 and SE 14.5; 95% CI 8.8–20.1 respectively). Increased rates of asthma attacks amongst sensitized children were also reported, with 44.2% of attacks being attributable to high levels of dog allergens and 30.3% attributable to high levels of cat allergens.44 A similar effect is seen in adolescents enrolled in an Inner-City Asthma Control Evaluation; with higher cat IgE levels being associated with a greater risk of having an asthma exacerbation within the previous year.47

Conversely, there is some research to suggest that exposure to such pets can in fact be a protective factor against allergy sensitisation in asthmatic children.21 Yet, these findings may be need to be revisited given that a follow-up study revealed how the “protective nature” of this pet exposure during infancy usually diminishes by adulthood.48 Clearly, due to the degree of conflict across available literature, further evidence is required to confirm the role of pet exposure in early life in the context of asthma outcomes. It should also be noted other animals such as horse, may be have relevant asthma-related sensitizations including cross-reactive molecules.49

Cockroach

In the United States, the two main species of cockroach are the German (Blatella germanica) and American (Periplaneta americana). The major allergens derived from these cockroaches are Bla g 1, Bla g 2 and Per a 1 found in the saliva, secretions, debris and faecal material.18 A population-based cross-sectional survey including 831 U.S homes found that detectable levels of cockroach allergen concentrations (Bla g 1) were present in approximately 63% homes.50 The study further found that such allergens exceeded concentrations of > 2U/g in 11% of living rooms and 13% of kitchen floors.43 This threshold marks the hypothesised level of allergic sensitisation and is therefore associated with a potential increase in asthma morbidity.51 Generally, high allergen levels are linked to high-dense populations of lower socioeconomic status in urban environments.50 Sensitisation to cockroach allergens is common amongst children living in these areas, with prevalence rates ranging from 60% to 80% across the available literature.18

Children with asthma sensitised to cockroach allergens, who are exposed during their childhood often suffer from increased symptoms and poor overall asthma control.18 The Inner-City Asthma Study involving 939 children aged 5 to 11 with moderate to severely diagnosed asthma investigated the relationship between cockroach-allergen sensitization and asthma outcomes.52 They found that those children who were both sensitized to Bla g 1 (69%) and exposed, were significantly more likely to have more asthma symptom days (P = 0.02), more school days missed (P = 0.04), and an increased number of asthma-related unscheduled visits (RR 1.40; 95% CI: 1.02–1.92) than their non-sensitised unexposed counterparts.52 A birth cohort study within inner cities explored anti-cockroach IgE levels in children aged 2 to 3 years and their associated symptomology.53 The study reported an association between higher anti-cockroach IgE levels and increased frequency of wheeze (OR 3.3; 95% CI, 1.8–6.2). This dose-response relationship was significant (P<0.001) with early wheeze in infancy being linked to increasing cockroach IgE levels.53 Children sensitised to cockroach allergens are also reported to be at an increased risk of asthma morbidity and will often experience more hospitalisations than those who are not allergic.54 The National Cooperative Inner-City Asthma Study found a significant (P = 0.001) increase in the rate of asthma-related hospitalizations (0.37 per year) in those children who were both sensitised and exposed to cockroach allergens compared to others (0.11 hospitalisations per year).

Rodents

There are two mouse allergens, Mus m 1 and Mus m 2. Mus m 1 (the dominant mouse allergen), is found primarily in mouse urine, and in smaller amounts in mouse epithelium.55–57 Mus m 2 is found in mouse hair and dander.55−587 The major rat allergen is Rat n 1.58

Mouse allergen has been found primarily in inner-city homes and schools, although it is found in other demographics as well.59 While the concentration of mouse allergen varies as much as 1000-fold between inner-city and non-inner-city environments,60 Mus m 1 was found in 82% of homes in a cross-sectional survey of the United Stated (US) population.50 A study of predominantly high-income allergic children in Boston found mouse allergen in 42% of their homes.61 In addition to direct exposure in homes, mouse allergen can be passively transferred from adults who have occupational exposure.62 While less prevalent than mouse allergen, rat allergen is also common especially in inner-city homes. A prospective study of inner-city homes of the National Cooperative Inner-City Asthma Study Population found that 33% of inner city homes had detectable rat allergen.63

The majority of the literature regarding the role of rodent allergy in asthma derives from the US, where rodent sensitization has been associated with adverse clinical outcomes in children with asthma including poorer lung function and an increased risk of asthma exacerbations.58,59 A prospective study of 144 children with asthma noted a significant association between mouse sensitization and acute asthma care visits (prevalence ratio [PR] 1.33; 95% CI: 1.07–1.65), higher FENO levels (P<0.01), and increased bronchodilator reversibility (PR 1.54; 95% CI: 1.09–2.19), noting mouse allergen to be the “major allergen of public health relevance in Baltimore City”.64 A study of 645 predominantly minority and low-income children with uncontrolled asthma documented an association between mouse sensitization and higher asthma treatment step levels (P<0.001), as well as higher composite asthma severity index (CASI) (P=0.02), with a dose response noted.65 A prospective study of 127 school aged children in inner-city Baltimore with symptoms of asthma noted that mouse sensitization was associated with 50% more asthma symptom days (incidence rate ratio [IRR] 1.5; 95% CI: 1.1–2.1), 80% more days of beta-agonist use (IRR 1.9; 95% CI: 1.3–2.5), and increased emergency Department visits for asthma (OR 2.1; 95% CI: 1.1–4.1) and hospitalizations for asthma (OR 36.6; 95% CI: 4.1–327.3) than other children, noting mouse allergy to be “an important cause of asthma morbidity”.66 The study of homes through the National Cooperative Inner-City Asthma Study found that sensitization and rat exposure were associated with asthma-related hospitalizations, unscheduled medical visits and days with reduced activity as a result of asthma.63

Outdoor Allergens

Pollens

Outdoor pollens are mostly from tree, grasses and weeds.67 Cross-reactivity among pollens is common.68 More than 150 pollen allergens have been identified, and vary by region and time of year.69 Pollens have an annual periodicity, and symptoms related to sensitization and allergy to those pollens tend to occur at approximately the same time every year in a specific region, albeit with variations in timing, duration and intensity of each pollen season.70,71 Pollen allergen is released into the air as a result of humidity, heavy rain and pollutants but release also varies by pH, time and temperature outdoors.70

The literature has clearly and consistently identified outdoor pollens as playing a role in asthma exacerbations in children. A systematic review and meta-analysis on outdoor pollen as a trigger for asthma emergency department presentations in children (N=14 studies) found a statistically significant increase in the percentage change in the mean number of asthma emergency Department presentations for an increase in 10 grass pollen grains per cubic meter of exposure, with positive correlations between pollen concentrations and emergency department presentations.72 The strongest association was among children aged 5–17 years of age. A five year case-crossover study of 2098 children in Australia found that an increase from 75th to 90th percentile of grass (OR 1.03; 95% CI: 1.01–1.07), weed (OR 1.05; 95% CI: 1.01–1.10), and unclassified pollen (OR 1.05; 95% CI 1.00–1.09) levels were significantly associated with the odds of asthma-related hospitalizations.73 A time-stratified case-crossover study of pediatric asthma exacerbations in Philadelphia found an increased odds of asthma exacerbation in association with tree pollen, with a positive exposure-response pattern.74

Outdoor Molds

Outdoor molds include Alternaria and Cladosporium and peak seasonally in the mid-summer with a reduction by the winter season.75 In dry and warm climates Alternaria, found in soil, seeds and plants, is the most common outdoor mold and in temperate regions Cladosporium, found in plants and vegetable matter, is the most common outdoor mold.75

Both Alternaria and Cladosporium sensitization have been associated with asthma exacerbations.76 In fact, in a study of asthma-related deaths among children and young adults in Chicago, mean mold spore levels but not tree, grass, or ragweed pollen levels were significantly higher for days on which asthma-related death occurred than for days on which no deaths occurred (z = 2.80, p < 0.005).77 The association with mold spore levels remained significant on multivariate logistic regression with mold spore counts, with the odds of an asthma-related death occurring being 1.2 times higher (95% CI 1.07–1.34) for every increase of 1000 spores per cubic meter in daily mold spore levels.

Allergen Exposure in an Era of Global Change

Impact of Social Determinants of Health on Allergen Exposure

There are various social determinants of health, and many may have an impact on asthma prevalence and morbidity within specific populations including: income and social status, physical environments such as housing, and race/ethnicity.14,78–80 Many of these determinants exert their effects through a complex network of interdependences and direct and indirect mechanisms that limit access and adherence to medication. Social determinants may also influence patient outcomes, ie asthma control and risk of exacerbations, specifically through their impact on exposures, such as viral infections and aeroallergen exposure.

It has been suggested that the relationship between poverty and asthma is higher in the US than in other high income countries, and that this relationship may be related to surrogates of poverty, in particular urban living – housing and aeroallergen exposure – that is worsening asthma in inner cities in the US more so than in other parts of the world.81 Data from the NHIS (N=17,110 children) notes that while compared to nonurban children, urban children (both poor and not poor) were at significantly increased risk of asthma, nonurban poor children were not (adjusted OR 1.03; 95% CI 0.72–1.48).82 Mouse and cockroach exposure in inner-city homes has been described as endemic.59 Studies have found cockroach and mouse allergen to be present in up to 85–95% of inner-city homes within the US23,83 and up to 81% of school classrooms.84 In a study of 150 urban-dwelling children with asthma, every tenfold increase in bed mouse allergen level was associated with an 87% increase in the odds of any asthma-related health care use among mouse-sensitized (OR 1.87; 95% CI 1.21–2.88) but not non-mouse sensitized children.85

Access to environmental measures that may ameliorate the impact of aeroallergen exposure, such as dust mite covers, reductions in humidity, mold amelioration measures, and indoor climate control are also less accessible to those facing adverse social determinants of health.14,80

Impact of Climate Change on Allergen Exposure

It has been noted that over 90% of children worldwide “breath polluted air.”13 While the impact of climate change on aeroallergen exposure remains incompletely understood, there is increasing evidence that it may have an impact on outdoor aeroallergens, and by extension, asthma control in children.13,86 Global warming has been projected to influence the duration and intensity of pollen seasons, and may lead to increased pollen production, prolonged pollen seasons, and increased pollen protein allergenicity.13,86 The alterations in weather patterns including rainfall and wind may cause pollen species to reach environments in which they had not previously been present, contributing to a shift in geographic pollen distributions.13 In addition, increasing air pollutants as a result of climate change have the potential to interact with outdoor aeroallergens in a number of ways including increasing pollen allergenicity, increasing peripheral airway binding and distribution, and enhancing and irritative and pro-inflammatory effect.13

Extreme weather events, such as thunderstorms, are increased as a result of climate change. These also have profound impacts on aeroallergen distribution and effect, and its impact on asthma. One such example is “thunderstorm asthma,” in which there is an increase in acute asthma attacks following a thunderstorm during pollen seasons (with those who remain indoors, and hence not exposed to pollens, less likely to be impacted).87 These events have been associated with thunderstorms all over the world, including in children.88 In a retrospective review of pediatric patients during September 2018 noted a 2.7 times increase in daily visits to the emergency department and 16 times increase in hospitalizations during a thunderstorm compared to other days in September.89 It has been hypothesized that the mechanism for these asthma exacerbations relates to high levels of pollen aeroallergens (in particular grass pollen, but also outdoor molds) swirling in the early parts of the thunderstorm, pulled up by the air current, ruptured due to humidity, and then impacting the respiratory tract in high concentrations.88,90 Another extreme weather event, flooding, can also impact aeroallergen distribution and exposure. In particular, houses will be exposed to more indoor molds.91 Wildfires, which have plagued the United States, Canada and Australia (among others), increase particulate matter (in particular PM2.5) and increase the risk of asthma exacerbations and hospitalizations.92,93

As with all elements of asthma, the impact of climate change is most poignantly felt in those facing other adverse determinants of health. It has been noted that adverse determinants (poverty, homelessness, race, social disparities) influence climate exposures, exacerbate their health impacts, and ultimately cause worse health outcomes (due to increased likelihood of other underlying chronic medical conditions, and reduced healthcare access).13

Impact of the COVID-19 Pandemic on Allergen Exposure

During the COVID-19 pandemic, there has been a dramatic reduction in asthma exacerbations and emergency department visits among children.94–96 There are many factors that are hypothesized to contribute to this reduction, including social distancing measures, use of masks and a decrease in infectious triggers. Another possible contributor is is a reduced exposure to outdoor seasonal aeroallergens.97 This may be compounded by the considerable reduction in outdoor air pollution that has been noted during the pandemic. Declines in outdoor ground-level nitrogen dioxide (NO2), and PM2.5 have been noted in over 30 countries during the early phases of the pandemic, attributed in part to reductions in vehicle emissions.98 A network of over 10,000 air quality stations in over 34 countries noted dramatic reductions in PM2.5. It was estimated that there were a net total of 89,000 pediatric emergency room visits avoided during lockdowns as a result of this reduction in outdoor air pollution, which

illustrate the potential health benefits gained by reducing ‘business as usual’ air pollutant emissions from economic activities primarily through finding alternative transportation solutions.99

The flip side of the COVID-19 pandemic is the increased time indoors, and as a result exposure to indoor aeroallergens such as HDM, and indoor air pollutants.100 Some studies have demonstrated that, even in children with HDM sensitization and asthma, there remains reductions in respiratory tract infections and asthma exacerbations despite increased indoor aeroallergen exposure.100 However others have noted that HDM exposure and COVID-19 can create “the perfect storm,” with a noted worsening in allergic symptoms during the lockdowns among HDM sensitized individuals.101 However, other factors may influence the impact of increased indoor time as well. For example, increased indoor time can result in increased exposure to second-hand smoke and indoor air pollutants.97 In addition, with increased use of household cleaning products and disinfectants there has been a significant increase in volatile organic compound concentrations within the home including indoor total volatile organic compound concentration and PM2.5 concentrations.102

Principles of Treatment

Avoidance and Removal Measures

For indoor allergens, the Global Initiative for Asthma (GINA) strategy does not recommend allergen avoidance as a general strategy,2 noting limited evidence of clinical benefit especially with a single-strategy indoor aeroallergen avoidance approach. GINA also notes that allergen avoidance strategies can be both “complicated and expensive, and there are no validated methods for identifying those who are likely to benefit.”2 If an approach is taken, especially if there are multiple allergies, a comprehensive approach is most likely to be beneficial.75

Measures to remove HDM within the home include mattress and pillow covers (pore diameter no more than 10 microns), regular washing of bedding in hot water, removal of stuffed toys upholstered furniture and carpeting, regular vacuuming, and keeping the humidity low in the home (<50%).75 In a systematic review of 20 studies in children and adolescents, multicomponent dust mite interventions reduced the number of asthma symptoms by 0.8 days per 2 weeks (21.0 symptom days per year) and reduced the number of asthma acute care visits by 0.57 visits per year.103 However, as noted by the GINA guidance, “this approach is complicated, expensive and is not generally recommended.”2 Reduction in humidity has the potential to reduce indoor mold exposure such as dehumidifiers and air conditioners. In addition, removing obvious mold from the home may play a role as well.75

The optimal approach to remove pet allergen from the home is removal of the pet itself from the home. However, even with pet removal it can take months for the pet aeroallergen to reduce to baseline. In a study of 15 homes during a 9-to 43-week period after cat removal, Fel d 1 levels declined gradually in most homes and by 20 to 24 weeks after cat removal, 8/15 were consistent with levels found in control homes without cats.104 Whether or not the pet is removed from the home, thoroughly cleaning the home and removal of any reservoirs for the allergen (upholstered furniture and carpeting) may be beneficial.75 Use of high-efficiency particulate air (HEPA) filters, mattress and pillow covers, and regular washing (in particular for dogs but only if twice a week or more)104 can be helpful if the pet remains in the home.77 However, whether or not this reduction in airborne allergen levels impacts asthma disease activity remains controversial.105 The GINA strategy notes limited evidence of clinical benefit for asthma with pet avoidance strategies.2 This may be partly because exposure to pet allergens occurs in schools, public buildings and public transportation even if the pet is removed from the home.2

Integrated pest management (IPM) strategies have demonstrated effectiveness in removing cockroach, mouse and rat allergen from the home.106 IPM includes sealing all cracks/holes in the home, cleaning surfaces with detergent, vacuuming with HEPA filtration, tracking powder (pesticide) on wall voids/pipe chases, snap traps, and familial education about food storage and kitchen cleaning.59,60 Simple interventions, such as insecticides, can make a significant difference. A recent study of 122 children with moderate to severe asthma noted that insecticidal bait in the homes resulted in few cockroaches within the homes (P<0.01); children in control homes without the bait had more asthma symptoms (P=0.03), unscheduled health care utilization (P=0.03) and worsening lung function (P=0.01) compared to children in the intervention group.107 Rodenticide can be considered in accordance with their Environmental Protection Agency-approved label indications if other measures of IPM are unsuccessful.58

For outdoor allergens, GINA notes that these are impossible to avoid completely.2

Closing doors and windows and remaining indoors when pollen and/or mold counts are highest may have a role in reducing exposure (although there is low quality evidence to support this intervention).2 Pollen calendars and monitoring of pollen and mold counts may be helpful at the individual and population level, as correlations are found between the pattern of pollen load and allergen content with asthma symptoms.108,109 Novel methods to predict pollen counts including mobile solutions are ongoing.110

Allergen Immunotherapy

Allergen immunotherapy (AIT) is a key treatment option for children with aeroallergen-induced IgE-mediated disease. The mechanisms underpinning the induction and maintenance of allergen-specific tolerance involve several immunologic pathways, including both innate and adaptive immune responses.111 There are two main types of AIT available – subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT).2 A range of aeroallergens are available, using purified extracts or recombinant allergens, unmodified or modified, in increasingly diverse and heterogeneously available commercial products.

Whilst a robust body of evidence supports the efficacy and safety of AIT in pediatric allergic rhinitis and rhinoconjunctivitis over 5 years of age, the knowledge base for asthma is less solid.111 Most data for this indication comes from children with mild-to-moderate asthma, with several systematic reviews supporting the efficacy and safety of AIT in these asthmatic children. Immunotherapy has been considered safe, effective in reducing asthma medication burden, and has the potential to have a disease progression preventative effect.112 Guidelines differ in their recommendation for use in pediatric asthma, based on age, asthma severity and specific allergens.2,111,114,

Shortcomings in available evidence include the diversity in selected populations (eg single or polysensitized), the sources and types of single/combined allergen products used with differing standardization and quality, the absence of validated biomarkers and clinically relevant outcomes, as well as the scarcity of comparative data between SCIT and SLIT. Differences in the evidence base between distinct allergens are particularly relevant, with more confidence in the benefits of AIT for selected pollens and HDM, lower strength of evidence supporting the use in selected molds (ie Alternaria), and considerable gaps regarding effectiveness of AIT for dogs, cats, horses and rodents, as well as other allergens.

Mitigating the Impact of Climate Change, Adverse Social Determinants, and COVID-19

The Global Alliance against Chronic Respiratory Diseases (GRD) which was initiated by the World Health Organization (WHO) has identified climate change prevention (or amelioration) as a respiratory public health priority.13 A position statement by the European Respiratory Society (ERS) on climate change and respiratory disease notes that “awareness and appropriate actions with respect to climate change” are a necessary and urgent intervention.91 A recent review article on the impact of climate change and allergic disease noted

We must take a moment and reflect on our role during this unique moment in the history of humanity. It is up to us reading this journal to step up, educate, create awareness, and advocate for the future of our patients and every person in the world … The medical profession is a trusted source of knowledge and can promote equitable climate solutions and health policies.13

In addition, this review article noted the impact of individual-level choices as they relate to our personal carbon footprint, can have a profound impact on climate change.13 The ERS provides a series of specific recommendations to reduce the impact of climate change including reducing emissions, improving home insulation and temperature control and reducing indoor pollution, although acknowledging that many gaps in the literature exist and that for certain exposures – such as pollens – little can be done.91

Determinants of health need to be increasingly considered in working with children with asthma and their families. As noted in a recent viewpoint, “to foster health at the population level, population health is best seen as a hybrid of public health and clinical Medicine, drawing from the traditions of both approaches.”114 Ongoing advocacy is required to reduce the impact that determinants of health have on the prevalence, and morbidity, of asthma in childhood moving forward, both at a clinical and at a policy level. Various solutions to maintain “healthy housing” have been proposed during the pandemic, to mitigate any impact of increased exposure to indoor aeroallergens and pollutants.97 These include smoking avoidance and cessation, keeping windows open frequently (unless it is high pollen season), and avoiding burning solid fuels for cooking.97

Conclusion and Future Steps

Allergens have an important and long-lasting role in the development of asthma, and asthma control. Despite individual variances in asthma endotype and phenotype, the role of allergens, as an important driver of Type-2 high disease, is likely to remain constant. There are societal and socioeconomic factors that increase the risk and impact of allergen sensitisation.

Currently the evidence around allergen avoidance and mitigation measures – including clinical and cost-effectiveness outcomes – is variable. Notwithstanding this, there is a need for further education about the impact of particular problems, for example rodent allergy. Currently, there is no mention of evaluation of rodent sensitization in either the Global Initiative for Asthma (GINA)115 or National Asthma Education and Prevention Program (Expert Panel Report, 3) guidelines.59,116 Advocacy efforts to provide affordable pest management strategies are necessary.59 Further research efforts are necessary to determine which pest management strategies are most effective in these communities.59 A consensus approach is required, and this should start with a. detailed process mapping international guidance around allergens.

Alongside this there is a need to consider allergens and climate change. The ERS position statement has identified several steps that are required moving forward, largely focused on research priorities. For example, they note research is needed on the clinical efficacy of interventions to mitigate the impact of climate change, the role of housing systems in respiratory disease including asthma, and identifying which children are most at risk due to the impacts of climate change.91

Regarding the impact of social determinants, moving forward, there remains much to learn. As we increasingly understand the various phenotypic and endotypic differences in pediatric asthma, and the role of personalized medicine, this evolving and exciting research may further guide our approach to some of these determinants such as access to care. The results of studies in inner cities may further inform approach. The role of these determinants in shaping policy and research needs moving forward remains to be seen, as does how policy and healthcare spending should reflect the role of these determinants.

Disclosure

RM Fernandes is/has been a member of DMCs and CECs of clinical trials by Ablynx, Janssen and Reviral. EM Abrams is an employee of Public Health Agency of Canada (PHAC); the views expressed are her own and not those of PHAC. Dr Ian P Sinha reports being a paid consult from Astra Zeneca. The authors report no other conflicts of interest in this work.

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For those looking for professional services for commercial air duct cleaning in Manhattan and Newark, New York, Air Ref Condenser Cleaning Corporation is the right choice.

This press release was orginally distributed by ReleaseWire

Moonachie, NJ — (ReleaseWire) — 03/28/2022 — The air duct system has a huge role to play in a commercial setting. The duct system prevents air contamination by removing dust, dirt, pollen, and other contaminants. If the air ducts are leaking, these contaminants get released into the indoor air, resulting in health hazards and other serious consequences.

With Air Ref Condenser Cleaning Corporation standing by their experience and expertise, commercial air duct cleaning is made easier. Periodic cleaning helps boost the system’s energy efficiency, increasing its performance to an optimum level.

An investment in commercial air duct cleaning in Manhattan and Newark, New York, pays off by keeping the commercial space safe and dirt-free. Plus, it removes the lingering odors, rendering the space worth using for prolonged commercial activities.

In the absence of such cleaning, allergens are more likely to spread in the air, causing health hazards contributing to increased absenteeism and sick leaves. This affects the performance and productivity in turn. Sometimes, attrition rates increase due to this.

Moreover, maximum indoor air quality problems stem from inefficient HVAC and air duct systems. Air Ref Condenser Cleaning Corporation has a team of experts with experience and skill to deliver quality services for air duct sanitation, commercial air duct cleaning, and HVAC duct cleaning.

The professionals go deep into the problems and figure out the issues contributing to the duct failure. They use the latest tools and technology to deliver the results that the clients and their employees deserve.

From site walk-through to blueprint review, they bring their superior experience in ensuring the ultimate cleaning of the unit. The technicians can often identify mold and mildew growth within the ductwork, moisture accumulation, perforations, leaks, and other possible issues.

For more information on cooling tower cleaning in Manhattan and New York City, New York, visit https://www.airrefcorp.com/cooling-tower-cleaning-weehawken-jersey-city-moonachie-newark-nj-new-york-city-ny/.

Call NY: (212) 594-0300or NJ: (201) 866-8500 for details.

About Air Ref Condenser Cleaning Corporation
Air Ref Condenser Cleaning Corporation has provided quality HVAC System Cleaning to clients in Moonachie, New York City, Weehawken, Newark, and Jersey City for over 50 years. Air Ref is the company customers turn to when they require portable cooling or heating equipment. They are aware that they give direct-to-site delivery and, if necessary, installation.

For more information on this press release visit: http://www.releasewire.com/press-releases/air-ref-condenser-cleaning-corporation-specializes-in-commercial-air-duct-cleaning-in-manhattan-and-newark-new-york-1355302.htm

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A residential HVAC system is a big investment, and yearly maintenance will prolong its life and keep it functioning efficiently. Every year, a licensed HVAC technician should visit Maple Falls homes to inspect systems for problems. Here, area homeowners will learn what to expect during an annual service call.

Meeting The Service Technician

When they arrive, the technician will come to the door and introduce themselves. Our technicians always arrive in vehicles with the company logo, and they wear uniforms with their first names prominently displayed. Every technician will provide his or her identification on request. With the homeowner’s consent, the technician will enter the home and ask where the circuit breaker and HVAC unit are located.

Indoor Evaluation

Once the company’s technicians find the breaker box and air conditioning unit, they’ll start the indoor part of the annual inspection. During the process, a tech will make several checks to ensure that the unit is operating at peak efficiency. They will:

• Switch the unit on, listening for strange noises

• Evaluate and test the system’s wiring, controls, and connections

• Clean various parts, including the blower, motor, and its housing

• Inspect the thermostat and test it for proper function, calibrating it if necessary

• Ensure that the HVAC system is under the correct electrical load

• Clean and inspect evaporator coils, drain lines, and drain pans

• Measure the temperature of the air that comes out of the ducts

• Check the ductwork for leaks

• Ensure that the HVAC system is working according to manufacturer specifications

Count on the team at LaVergne’s Plumbing to provide the yearly services needed to keep residential HVAC units in great shape. Contact a team member today to book an appointment for yearly HVAC maintenance.

Outdoor Inspection

After they’ve finished the indoor inspection, the technician will evaluate the system’s outdoor components. Those parts of the system are just as crucial as the indoor air handler as far as the family’s comfort is concerned. During this time, the technician will:

• Measure the refrigerant level and add more if needed

• Check the AC compressor for signs of wear, tear, and damage

• Inspect connections and wiring for damage

• Clean the unit’s housing and condenser coil

• Remove leaves, dirt, and debris from the area near the unit

• Ensure the area around the unit is free of obstructions

Yearly service reduces the risk of system failure and helps homeowners find small problems before they become big and unmanageable. Call or click today to make an appointment.

Count On The Pros For Residential HVAC Service, Maintenance, And Repairs

Yearly HVAC maintenance is the best and most cost-effective way to protect the owner’s investment. While Maple Falls homeowners can schedule visits at any time, it’s best to do it during the fall or winter, as that’s when the demand for air conditioning service is low. Additionally, scheduling yearly maintenance provides homeowners with the reassurance of knowing that their heating and air conditioning units will keep them comfortable all year long. Heating and air conditioning services are available, request additional information by phone or contact the team online to schedule.

Media Contact
Company Name: LaVergne’s Plumbing & Heating
Contact Person: Media Relations
Email: Send Email
Phone: 360-685-8098
Address:6001 Lawrence Rd
City: Everson
State: WA
Country: United States
Website: lavergneplumbing.com

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